General Information

  • ID:  hor002517
  • Uniprot ID:  NA
  • Protein name:  Tyr-W-MIF-1
  • Gene name:  NA
  • Organism:  NA
  • Family:  NA
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  YPWG
  • Length:  4
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T4 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Antinociceptive effect
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002517_AF2.pdbhor002517_ESM.pdb

Physical Information

Mass: 57526 Formula: C27H31N5O6
Absent amino acids: ACDEFHIKLMNQRSTV Common amino acids: GPWY
pI: 6.09 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 1
Hydrophobicity: -105 Boman Index: 313
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 0
Instability Index: 522.5 Extinction Coefficient cystines: 6990
Absorbance 280nm: 2330

Literature

  • PubMed ID:  17343845
  • Title:  A Tyr-W-MIF-1 Analog Containing D-Pro2 Discriminates Among Antinociception in Mice Mediated by Different Classes of Mu-Opioid Receptors